ba60f6118d1e33cbb51e21 20240428021649579 hossein.nostalgia@yahoo.com:knbn hossein.nostalgia@yahoo.com WEB-FORM Afghanistan Journal of Basic Medical Science AJBMS 30056632 10.62134/ajbms/ https://ajbms.knu.edu.af/index.php/ajbms/index 04 15 2024 2 2 10.62134/ajbms/v2.i2.khatamuni https://ajbms.knu.edu.af/index.php/ajbms/issue/view/6 Research and Technology Center, Khatam-Al Nabieen University, Kabul, Afghanistan Mahdi Nowroozi Muhammad Younis Noori Medical Sciences Research Center, Ghalib University, Kabul, Afghanistan Sayed Hussain Mosawi Medical Sciences Research Center, Ghalib University, Kabul, Afghanistan Introduction: Polyfluorooctanoic acid (PFOA) is a member of the polyfluoroalkyl substances (PFAS) family that is widely used in various industries due to its unique chemical and physical properties, including high stability in harsh environmental and biological conditions. However, the widespread distribution of PFOA in nature, such as in air, water, food, and farms, has raised concerns about its potential health effects on humans and other organisms. PFOA has been linked to various diseases and organ dysfunction, primarily attributed to its detrimental impact on essential cellular components such as DNA, RNA, and epigenetic factors, which are critical for proper cell function and development. To better understand the dosage levels and exposure durations that can lead to adverse effects, laboratory experiments, as well as in vivo and in vitro studies, are being conducted to ensure that PFOA does not pose any negative impacts on the environment, human health, and organs. Furthermore, efforts are being made to address this issue by exploring alternative chemical materials or degradation methods to mitigate the presence of PFOA. Therefore, the aim of this research is to gather information from various articles that investigate the doses and mechanisms of PFOA's negative impact on health and organ function. This compilation of information will serve as a valuable resource for researchers studying PFOA and provide a comprehensive reference for those seeking general knowledge on PFOA-related topics in the context of health diseases and the medical field. 04 15 2024 39 64 10.62134/ajbms/v2.i2.khatamuni.5 https://ajbms.knu.edu.af/index.php/ajbms/article/view/25/version/25